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Drug nameCyproterone
DescriptionAn anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]
DrugBankPrimary Accession Number: DB04839
DIN00704423
TypeApproved, Investigational, Small Molecule
IndicationFor the palliative treatment of patients with advanced prostatic carcinoma.
Mechanism of ActionThe direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone.
AbsorptionCompletely absorbed following oral administration.
ToxicityNot available
Protein BindingNot available