|Description||A selective alpha-1-adrenergic blocker that lowers serum cholesterol. It is also effective in the treatment of hypertension. [PubChem]|
|DrugBank||Primary Accession Number: DB00590|
|Type||Approved, Small Molecule|
|Indication||For treatment and management of Hypertension and urinary obstruction symptoms of BPH.|
|Mechanism of Action||Doxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.|
|Toxicity||Symptoms of overdose include hypotension. Oral LD50 is greater than 1000 mg/kg in mice and rats.|
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