You need to load/activate the cURL extension (
Drug nameDoxazosin
DescriptionA selective alpha-1-adrenergic blocker that lowers serum cholesterol. It is also effective in the treatment of hypertension. [PubChem]
DrugBankPrimary Accession Number: DB00590
TypeApproved, Small Molecule
IndicationFor treatment and management of Hypertension and urinary obstruction symptoms of BPH.
Mechanism of ActionDoxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
ToxicitySymptoms of overdose include hypotension. Oral LD50 is greater than 1000 mg/kg in mice and rats.
Protein Binding98%