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Drug nameDoxazosin
DescriptionA selective alpha-1-adrenergic blocker that lowers serum cholesterol. It is also effective in the treatment of hypertension. [PubChem]
DrugBankPrimary Accession Number: DB00590
DIN02243217
TypeApproved, Small Molecule
IndicationFor treatment and management of Hypertension and urinary obstruction symptoms of BPH.
Mechanism of ActionDoxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
Absorption65%
ToxicitySymptoms of overdose include hypotension. Oral LD50 is greater than 1000 mg/kg in mice and rats.
Protein Binding98%