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Drug nameAlfuzosin
DescriptionAlfuzosin (INN, provided as the hydrochloride salt) is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. [Wikipedia]
DrugBankPrimary Accession Number: DB00346
DIN02245565
TypeApproved, Investigational, Small Molecule
IndicationFor the treatment of the signs and symptoms of benign prostatic hyperplasia.
Mechanism of ActionAlfuzosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
AbsorptionAbsorption is 50% lower under fasting conditions
ToxicitySide effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.
Protein Binding82%-90%