|Description||Alfuzosin (INN, provided as the hydrochloride salt) is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. [Wikipedia]|
|DrugBank||Primary Accession Number: DB00346|
|Type||Approved, Investigational, Small Molecule|
|Indication||For the treatment of the signs and symptoms of benign prostatic hyperplasia.|
|Mechanism of Action||Alfuzosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.|
|Absorption||Absorption is 50% lower under fasting conditions|
|Toxicity||Side effects are dizziness (due to postural hypotension), upper respiratory tract infection, headache, and fatigue.|
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