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Drug nameFlutamide
DescriptionAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
DrugBankPrimary Accession Number: DB00499
TypeApproved, Small Molecule
IndicationFor the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
Mechanism of ActionFlutamide is a nonsteroidal antiandrogen that blocks the action of both endogenous and exogenous testosterone by binding to the androgen receptor. In addition Flutamide is a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen.
AbsorptionRapidly and completely absorbed
ToxicityIn animal studies with flutamide alone, signs of overdose included hypoactivity, piloerection, slow respiration, ataxia, and/or lacrimation, anorexia, tranquilization, emesis, and methemoglobinemia.
Protein Binding94-96%