|Description||Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.|
|DrugBank||Primary Accession Number: DB00014|
|Indication||Breast cancer; Prostate carcinoma; Endometriosis|
|Mechanism of Action||ZOLADEX is a synthetic decapeptide analogue of LHRH. ZOLADEX acts as a potent inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. The result is sustained suppression of LH and serum testosterone levels.|
|Absorption||Inactive orally, rapidly absorbed following subcutaneous administration|
|Toxicity||No experience of overdosage from clinical trials|
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