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Drug namePrazosin
DescriptionA selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud`s syndrome, prostatic hypertrophy, and urinary retention. [PubChem]
DrugBankPrimary Accession Number: DB00457
DIN01910302
TypeApproved, Small Molecule
IndicationFor treatment of hypertension and chronic heart failure.
Mechanism of ActionPrazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
AbsorptionWell-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).
ToxicityNot available
Protein Binding97%