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Drug nameBicalutamide
DescriptionBicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It binds to the androgen receptor.
DrugBankPrimary Accession Number: DB01128
DIN02184478
TypeApproved, Small Molecule
IndicationFor treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Mechanism of ActionBicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.
AbsorptionBicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.
ToxicityNot available
Protein Binding96%