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Drug nameCiprofloxacin
DescriptionA broad-spectrum antimicrobial carboxyfluoroquinoline. [PubChem]
DrugBankPrimary Accession Number: DB00537
TypeApproved, Investigational, Small Molecule
IndicationFor the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
Mechanism of ActionThe bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
AbsorptionRapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.
ToxicityThe major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.
Protein Binding20 to 40%