DENdb is a centralized on-line repository of predicted enhancers derived from multiple human cell-lines. DENdb integrates enhancers predicted by five different methods (ChromHMM, Segway, RFECS, CSI-ANN, and ENCODE integrated annotation) generating an enriched catalogue of enhancers for each of the analyzed cell-lines.
DENdb contains overlap of enhancers with DNase I hypersensitive regions, and transcription factor binding sites. It also provides means to investigate enhancer interactions with DNA using several chromatin interaction assays, and the ability to explore genes neighbouring enhancers.
DENdb is based on human genome version hg19.
Crystals of a DNase protein (Alex McPherson, University of California, Irvine. Courtesy of NIH)