A mutation fingerprint resource providing tracking of SARS-CoV-2 variants worldwide.
SARS-CoV-2 genome isolates from COVID-19 patients are being increasingly and regularly sequenced worldwide. These isolate genome sequence data is becoming available from several countries, including Saudi Arabia. These isolate genome sequences can provide fingerprints (a snapshot of mutations) of the evolving virus as it incubates through different populations in different countries. These fingerprints can lead to the virus transmission route and timeline.
Additionally, these fingerprints, especially amino-acid changing (non-synonymous) mutations, assess the evolving capability of the virus as it gets stronger or weaker over time. For example, non-synonymous changes in the Spike protein (Receptor Binding Region) can affect the virus’ binding to the ACE2 receptor on human cells, a first step in causing the infection.
We obtained SARS-CoV-2 sequence data from several sources in Saudi Arabia (CDC, Hospitals) and worldwide. We process isolates genomes to first obtain a fingerprint of mutations appearing in sampled populations across different locations that helps to understand SARS-CoV-2 variants and their infection track.