Drug nameDoxazosin
DescriptionA selective alpha-1-adrenergic blocker that lowers serum cholesterol. It is also effective in the treatment of hypertension. [PubChem]
DrugBankPrimary Accession Number: DB00590
DIN02243217
TypeApproved, Small Molecule
IndicationFor treatment and management of Hypertension and urinary obstruction symptoms of BPH.
Mechanism of ActionDoxazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
Absorption65%
ToxicitySymptoms of overdose include hypotension. Oral LD50 is greater than 1000 mg/kg in mice and rats.
Protein Binding98%
Interactions
RXListhttp://www.rxlist.com/cgi/generic/doxazo.htm
KEGGdrug: Not available / compound: C06970
PubChemcompound: 3157 / substance: 9184
PharmGKBPA449407
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Target
NameGeneEntrezIDSwissprotSNP
Alpha-1A adrenergic receptorADRA1A148ADA1A_HUMANrs56318220 rs56233953 rs59765666 rs1048101 rs56394436 rs7833704 rs3730287 rs3730247 rs2229126 rs2229125 rs2229124 rs1496121 rs1383914 rs1048102
Alpha-1B adrenergic receptorADRA1B147ADA1B_HUMANrs34322837 rs8192450 rs8192448 rs3730284 rs3729604 rs2229181
Alpha-1D adrenergic receptorADRA1D146ADA1D_HUMANrs55915202 rs55926349 rs35105284 rs3803964
FilesDB00590.mol | DB00590_2005-02-01.pdf | pdb_331413881309-0.pdb | sdf_8293610014996-0.sdf |
Smilesisomeric:
COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)[C@H]1COC2=CC=CC=C2O1
canonical:
COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1

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