Drug nameEpothilone D
DescriptionNot available
DrugBankPrimary Accession Number: DB01873
DINNot available
TypeExperimental, Investigational, Small Molecule
IndicationInvestigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.
Mechanism of ActionThe principal mechanism of the epothilone class is inhibition of microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing.
AbsorptionNot available
ToxicityNot available
Protein BindingNot available
Interactions
RXListNot available
KEGGdrug: Not available / compound: C12039
PubChemcompound: 6440032 / substance: 14194
PharmGKBNot available
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Target
NameGeneEntrezIDSwissprotSNP
Tubulin alpha-1 chainTUBA17277TBA1_HUMAN
Tubulin alpha-ubiquitous chainTUBA1B10376TBAK_HUMAN
Tubulin alpha-2 chainTUBA27278TBA2_HUMAN
Tubulin alpha-3 chainTUBA37846TBA3_HUMAN
Tubulin alpha-6 chainTUBA684790TBA6_HUMAN
Tubulin alpha-8 chainTUBA851807TBA8_HUMANrs2234334 rs2234333 rs2234332 rs2234331 rs2234328 rs2234327 rs362203
Tubulin beta-1 chainTUBB181027TBB1_HUMANrs35565630 rs35989782 rs6070697 rs163777 rs45599044 rs41303899 rs35505670 rs34793043 rs34074666 rs6128481 rs463312 rs415064
Tubulin beta chainTUBB2A7280TBB2_HUMANrs41300839 rs17849443 rs17421528 rs1133240 s11550262 rs11550260 rs11550258 rs3209186 rs3209185 s2231370 rs1140970 rs1133247 rs1133246 rs1133245 rs1133244 rs1054419 rs1054310 rs1054309 rs1054305 rs1054304
Tubulin beta-2C chainTUBB2C10383TBB2C_HUMANrs13298809 rs11545615 rs11545614 rs11545613 rs11545611 s11545609 rs11545608 rs11545607 rs11545606 rs11545604 rs11545603 rs9330200 rs4073101 rs4072054 rs9897
Tubulin beta-3 chainTUBB310381TBB3_HUMANrs34174718 rs11554952 rs11554951 rs4539594
Tubulin beta-4 chainTUBB410382TBB4_HUMANrs2071347 rs1053267 rs1053263 rs1053262 rs1053260
Tubulin beta-4q chainTUBB4Q56604TBB4Q_HUMANrs9884710 rs2077107 rs57188123 rs17799221 rs9995127 rs4618356 rs4613614 rs4613613 rs4277824 rs4277823 rs4277822 rs4080710 rs3959347 rs3812545 rs2898750 rs2411551
FilesDB01873.mol | pdb_144680725473-0.pdb | sdf_7211979414996-0.sdf |
Smilesisomeric:
C[C@H]1CCCC(C)=C/C[C@@H](OC(=O)C[C@@H](O)C(C)(C)C(=O)[C@@H](C)[C@@H]1O
)C(C)=CC1=CSC(C)=N1
canonical:
CC1CCCC(C)=CCC(OC(=O)CC(O)C(C)(C)C(=O)C(C)C1O)C(C)=CC1=CSC(C)=N1

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