Drug nameLeuprolide
DescriptionSynthetic 9 residue peptide analog of gonadotropin releasing hormone.
DrugBankPrimary Accession Number: DB00007
DINNot available
TypeApproved, Biotech, Investigational
IndicationFor treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
Mechanism of ActionLeuprolide binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.
AbsorptionNot available
ToxicityNot available
Protein Binding46%
Interactions
RXListhttp://www.rxlist.com/cgi/generic/eligard.htm
KEGGdrug: Not available / compound: C07612
PubChemcompound: 3911 / substance: 9814
PharmGKBPA450203
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Target
NameGeneEntrezIDSwissprotSNP
Gonadotropin-releasing hormone receptorGNRHR2798GNRHR_HUMANrs35400155 rs28933074 rs13149772 rs13130501 rs4986942
FilesDB00007.mol | DB00007_2004-04-01.pdf | pdb_3375791324834-0.pdb | sdf_3098870214996-0.sdf |
Smilesisomeric:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CC(C)C)NC(=O)[
C@@H](CC(C)C)NC(=O)[C@@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](CO)NC(=O)[C@H](
CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H]1CCC(=O)N1
canonical:
CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C
(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(=O)C(CC1=CNC2=CC=CC=C12)NC(=O)C(CC1=CN=
CN1)NC(=O)C1CCC(=O)N1

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