Drug nameParicalcitol
DescriptionParicalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
DrugBankPrimary Accession Number: DB00910
DIN02266202
TypeApproved, Investigational, Small Molecule
IndicationFor treatment of secondary hyperparathyroidism associated with chronic kidney disease (CKD) Stage 3 and 4
Mechanism of ActionParicalcitol is a synthetic, biologically active vitamin D analog of calcitriol with modifications to the side chain (D2) and the A (19-nor) ring. Preclinical andin vitro studies have demonstrated that paricalcitol`s biological actions are mediated through binding of the VDR, which results in the selective activation of vitamin D responsive pathways. Vitamin D and paricalcitol have been shown to reduce parathyroid hormone levels by inhibiting PTH synthesis and secretion.
AbsorptionWell absorbed
ToxicityNot available
Protein Binding99.8% (bound to plasma proteins)
Interactions
RXListhttp://www.rxlist.com/cgi/generic4/zemplar_caps.htm
KEGGdrug: D00930 / compound: C08127
PubChemcompound: 5281104 / substance: 10327
PharmGKBPA450798
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Cytochrome P450 24A1 (CYP24A1)CYP24A11591Q07973rs45593642 rs56075956
Cytochrome P450 3A4 (CYP3A4)CYP3A41576P08684rs13306281
UDP-glucuronosyltransferase 1-4 (UGT1A4)UGT1A454657P22310s5031015
Target
NameGeneEntrezIDSwissprotSNP
Vitamin D3 receptorVDR7421VDR_HUMANrs731236 rs12721365 rs2228570 rs35435255 rs34189316 s11832059 rs11574115 rs11574090 rs2228572 rs4987032 rs2229829 rs2229828
FilesDB00910.mol | DB00910_2005-05-01.pdf | pdb_2202241624834-0.pdb | sdf_8778610314996-0.sdf |
Smilesisomeric:
C[C@H](C=C[C@H](C)C(C)(C)O)[C@H]1CC[C@@H]2[C@]1(C)CCCC2=C/C=C1/C[C@@H]
(O)C[C@H](O)C1
canonical:
CC(C=CC(C)C(C)(C)O)C1CCC2C1(C)CCCC2=CC=C1CC(O)CC(O)C1

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