Drug nameQuinestrol
DescriptionThe 3-cyclopentyl ether of ethinyl estradiol.
DrugBankPrimary Accession Number: DB04575
DINNot available
TypeApproved, Small Molecule
IndicationUsed in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
Mechanism of ActionEstrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
AbsorptionAbsorbed following oral administration.
ToxicitySymptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
Protein BindingNot Available
Interactions
RXListNot available
KEGGdrug: D00576 / compound: C07619
PubChemcompound: 9046 / substance: 7847642
PharmGKBPA164749042
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Target
NameGeneEntrezIDSwissprotSNP
Estrogen receptorESR12099ESR1_HUMANrs2228480 rs2077647 rs4986934 rs1801132 rs34840398 rs17847076 rs17847067 rs17847065 rs9341069 rs9341068 rs9340802 rs9340773 rs1141584 rs746432
FilesDB04575.mol | pdb_3944006825473-0.pdb | sdf_1596746214996-0.sdf |
Smilesisomeric:
C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(OC3CCCC3)=C4)[C@@H]1CC[C@@]2(O)C#C
canonical:
CC12CCC3C(CCC4=C3C=CC(OC3CCCC3)=C4)C1CCC2(O)C#C

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