Drug nameBicalutamide
DescriptionBicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It binds to the androgen receptor.
DrugBankPrimary Accession Number: DB01128
DIN02184478
TypeApproved, Small Molecule
IndicationFor treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Mechanism of ActionBicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.
AbsorptionBicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.
ToxicityNot available
Protein Binding96%
Interactions
RXListhttp://www.rxlist.com/cgi/generic3/bicalutamide.htm
KEGGdrug: D00961 / compound: C08160
PubChemcompound: 56069 / substance: 193420
PharmGKBPA164746255
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Target
NameGeneEntrezIDSwissprotSNP
Androgen receptorAR367ANDR_RABITrs55686369 rs35025615 rs9332972 rs9332971 rs9332970 rs9332969 rs9332968 rs5902610 rs3032358 rs1800053 rs6154 rs6153 rs6152
Estrogen receptor betaESR22100ESR2_HUMANrs1256049 rs17226088 rs60101369 rs58256696 rs1256054 rs56926155 rs45624541 rs34624204 rs1541060
Interleukin-6IL63569IL6_HUMANrs56383910 rs34709428 rs34280821 rs34012176 rs13306435 rs11544633 rs2069860 rs2069849 rs2069830
FilesDB01128.mol | DB01128_146.pdf | DB01128_2005-05-01.pdf | pdb_7871662024834-0.pdb | sdf_4511287714996-0.sdf |
Smilesisomeric:
C[C@](O)(CS(=O)(=O)C1=CC=C(F)C=C1)C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)F
canonical:
CC(O)(CS(=O)(=O)C1=CC=C(F)C=C1)C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)F

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