Drug nameCephalexin
DescriptionA semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem]
DrugBankPrimary Accession Number: DB00567
TypeApproved, Small Molecule
IndicationFor the treatment of respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes; otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis; skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes; bone infections caused by Staphylococcus aureus and/or Proteus mirabilis; genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
Mechanism of ActionCephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.
AbsorptionWell absorbed from the gastrointestinal tract
ToxicitySymptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. The oral median lethal dose of cephalexin in rats is >5000 mg/kg.
Protein Binding14%
KEGGdrug: D00263 / compound: C06895
PubChemcompound: 27447 / substance: 625390
Metabolizing Enzymes
Penicillin-binding proteins 1A/1BpbpAQ8XJ01_CLOPE
FilesDB00567.mol | DB00567_2004-01-01.pdf | DB00567_512.pdf | pdb_6789661524834-0.pdb | sdf_6830249014996-0.sdf |

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