Drug nameCiprofloxacin
DescriptionA broad-spectrum antimicrobial carboxyfluoroquinoline. [PubChem]
DrugBankPrimary Accession Number: DB00537
DIN02248439
TypeApproved, Investigational, Small Molecule
IndicationFor the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
Mechanism of ActionThe bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
AbsorptionRapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.
ToxicityThe major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.
Protein Binding20 to 40%
Interactions
RXListhttp://www.rxlist.com/cgi/generic/cipro.htm
KEGGdrug: D00186 / compound: C05349
PubChemcompound: 2764 / substance: 192835
PharmGKBPA449009
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Cytochrome P450 1A2 (CYP1A2)CYP1A21544P05177rs740602 rs17853490
Target
NameGeneEntrezIDSwissprotSNP
Serum albuminALB213ALBU_HUMANrs962004 rs61579038 rs3210154 rs60826059 rs59597814 rs59439476 rs59066571 rs58639526 rs58624704 rs57636959 rs56042353 rs56167251 rs36067576 rs35683929 rs28930976 rs28930975 rs17854155 rs17854154 rs17853503 rs17853250 rs3210210 rs17400586 rs11538232 rs11538231 rs11538230 rs11538229 rs11538228 rs11538227 rs11538226 rs11538225 rs11538224 rs11538223 rs11538222 rs11538221 rs11538220 rs11538217 rs11538216 rs11538215 rs11538214 rs11538213 rs11538212 rs11538209 rs11538208 rs11538206 rs3210163 rs3204504 rs1140450 rs1140449 rs1063469
DNA topoisomerase 2-alphaTOP2A7153TOP2A_HUMANrs61054733 rs57842097 rs35858802 rs35036837 rs34370875 rs34300454 rs34273139 rs34270904 rs34209857 rs34147280 rs28969502 rs17680289 rs11656816 rs11540720 rs1804538 rs1804537 rs1141364 rs1061692
Acriflavine resistance protein BacrBACRB_ECOLI
DNA gyrase subunit AgyrAGYRA_HAEINrs41274928 rs2273709 rs6917902 rs59298334 rs941849 rs45597237 rs45496798 rs41274936 rs41274934 rs35768540 rs35708170 rs35514919 rs35085988 rs34716183 rs11962520 rs9472022 rs4714672 rs3215697 rs2841640
DNA topoisomerase 4 subunit AparCPARC_HAEINrs41274928 rs2273709 rs6917902 rs59298334 rs941849 rs45597237 rs45496798 rs41274936 rs41274934 rs35768540 rs35708170 rs35514919 rs35085988 rs34716183 rs11962520 rs9472022 rs4714672 rs3215697 rs2841640 s6917902
FilesDB00537_2004-08-01.pdf |
Smilesisomeric:
OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O
canonical:
OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O

© 2010-2020 All rights reserved. King Abdullah University of Science and Technology, All rights reserved