Drug nameConjugated Estrogens
DescriptionConjugated estrogens, a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics.
DrugBankPrimary Accession Number: DB00286
DIN02239655
TypeApproved, Small Molecule
IndicationFor the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
Mechanism of ActionEstrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary.
AbsorptionWell absorbed
ToxicityNausea and vomiting
Protein Binding90% bound to plasma proteins
Interactions
RXListhttp://www.rxlist.com/cgi/generic/conest.htm
KEGGdrug: D00312 / compound: Not Available
PubChemcompound: 9919 / substance: 7847378
PharmGKBNot available
Metabolizing Enzymes
NameGeneEntrezIDUniprotSNP
Catechol O-methyltransferase (COMT)COMT1312P21964rs769224 rs13306279
Cytochrome P450 19 (Aromatase)CYP19A11588P11511rs45581136 rs60308277
Cytochrome P450 1A2 (CYP1A2)CYP1A21544P05177rs740602 rs17853490
Cytochrome P450 3A4 (CYP3A4)CYP3A41576P08684rs13306281
Target
NameGeneEntrezIDSwissprotSNP
Estrogen receptorESR12099ESR1_HUMANrs2228480 rs2077647 rs4986934 rs1801132 rs34840398 rs17847076 rs17847067 rs17847065 rs9341069 rs9341068 rs9340802 rs9340773 rs1141584 rs746432
FilesDB00286.mol | DB00286_2003-06-01.pdf | DB00286_696.pdf | pdb_813648901309-0.pdb | sdf_3013517114996-0.sdf |
Smilesisomeric:
[Na+].C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(OS([O-])(=O)=O)=C4)[C@@H]1CCC2
=O
canonical:
[Na+].CC12CCC3C(CCC4=C3C=CC(OS([O-])(=O)=O)=C4)C1CCC2=O

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