DES-TCELL

Welcome to the DES-Tcell, a next-generation knowledge-mining resource focused on T-cells and their association with immune responses and disease development.

In our body, the immune system works as a protective shield against invading pathogens, such as bacteria, viruses, parasites, and abnormal cells. One of the critical components of the immune system is T-cells, which play an essential role in host cellular immune responses that protect the body from cancer, infection, and other harmful invaders. T-cells also play a pivotal role in regulating immune responses by orchestrating the function of other immune cells. However, T-cell defects can result in immune dysregulation leading to immune-mediated diseases. Accordingly, the volume of literature focused on T-cells is increasing annually, making data analysis challenging.

To support T-cell research and explore links between different factors associated with T-cells and their role in immune responses and diseases, we processed all relevant articles published in abstracts (PubMed) and full-text (PubMed Central) articles, and based on such information, a knowledgebase (KB) named DES-TCell was developed. DES-TCell is a platform that enables researchers to explore all T-cell related research. This platform employs concepts/terms from 15 curated topic-specific dictionaries mapped to the 1,547,415 documents for analyses.

DES-TCell allows exploring:

  1. individual statistically enriched concepts,
  2. individual pairs of concepts,
  3. co-occurrence of all concepts with an individual concept,
  4. interactive heterogeneous networks of associated concepts,
  5. hypotheses generated through semantic similarity, and
  6. export of the user’s results.

DES-TCell presents to users statistically enriched single and associated concepts based on a default false discovery rate (FDR) below 0.05, where FRD is calculated based on Benjamini–Hochberg procedure for correction for multiplicity testing.