Database Summary
  Description:
  Selected dictionaries: Human Genes+Proteins  Disease Related Concepts  Pathways  Sponge Compounds  Mode of action 

Searching for:BINDING POLYMERIZATION
Abstracts found:27

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PMIDTitleDisplay
10572005 Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.  
11221827 In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.  
11879196 Mode of inhibition of HIV-1 reverse transcriptase by polyacetylenetriol, a novel inhibitor of RNA- and DNA-directed DNA polymerases.  
15289305 Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines.  
15710041 Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain.  
16020666 The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth.  
16192358 Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity.  
17599353 A structural basis for regulation of actin polymerization by pectenotoxins.  
18298079 Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells.  
1874739 Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.  

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